Stem Cell Blog

Употребата на матичните клетки од папочна врвца рапидно се зголемува. Пред 10 години крвта од папочна врвца можеше да лекува околу 40 состојби, но денес таа бројка е над 80. Со нетрпение очекуваме нови терапии за болести и нарушувања како што се дијабет, аутизам и мозочен удар, можете да бидете во тек со најновите случувања во регенеративната медицина на нашиот блог за матични клетки.



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In a study first published in April’s edition of Advanced Functional Materials, researchers found that stem cells boost natural repair following cardiac arrest.

The most common consequence of cardiac arrest is brain injury. Decreased blood flow and oxygen to the brain can result in damage to specific areas such as the temporal lobe, which is responsible for memories. [1]

According to the British Heart Foundation, there are around 30,000 out of hospital cardiac arrests in the UK per year, with survival rates of only 1 in 10.

While there are currently steps towards improving these survival rates – mainly public awareness and educational campaigns focused on immediate response [2] – better survival rates potentially means more patients suffering from brain injury, which can range in severity.

What researchers at the University of Maryland School of Medicine in the U.S. have found is that neural stem cells can help with repairing post-cardiac arrest brain damage when their carbohydrate structure is manipulated. [3]

In an animal study using rats, scientists applied sugar molecules to the neural stem cells in a process called glycoengineering.

It’s thought that the application of these sugar molecules provide the neural stem cells with a better chance of retention and integration within the harsh microenvironment of the brain.

Researchers examined the efficacy of the ‘sugar-coated’ neural stem cells that had been pretreated with TProp (the name of the modified sugar molecule applied) with naive human neural stem cells.

They found through subsequent testing that the stem cells that had been pretreated with TProp improved brain function substantially, along with reducing anxiety and depression-related behaviours.

The ability for synapses to modify the strength of their connections (otherwise known as synapse plasticity) also improved, with the TProp group also demonstrating a reduction in neuroinflammation in the central nervous system.

Overall, the findings from the University of Maryland are promising as they indicate that these glycoengineered stem cells could help regenerate connections between synapses in the brain that have been affected by cardiac arrest related injury in humans.

The next steps will involve tests on larger animals before hopefully moving to a clinical study.

If you want to know more about how you can save your baby’s powerful stem cells, fill out the form below for your free welcome pack.

References

[1] (2023, July 7). Can a heart attack cause brain damage? Medical News Today. https://www.medicalnewstoday.com/articles/heart-attack-brain-damage#effects

[2] Horriar, Lina et al. “Improving survival after cardiac arrest in Europe: The synergetic effect of rescue chain strategies.” Resuscitation plus vol. 17 100533. 21 Dec. 2023, doi:10.1016/j.resplu.2023.100533

[3] (2024, May 9). Stem Cell Therapy Boosts Natural Repair After Cardiac Arrest. University of Maryland Baltimore. https://www.umaryland.edu/news/archived-news/may-2024/stem-cell-therapy-boosts-natural-repair-after-cardiac-arrest.php


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Researchers at Vienna University of Technology have taken an important step in making lab-grown cartilage a possibility by utilising a new technique involving 3D printing and stem cells. [1]

The process involves a high-resolution 3D printing process to create small, football-shaped spheres that act like porous scaffolds within which differentiated cartilage stem cells can sit.

These spheroid scaffolds can then be molded into various shapes in order to fit like puzzle pieces into seamless tissue structures.

One of the main challenges in attempting to form artificial cartilage using stem cells thus far has been the inability for scientists to leverage much control over the shape of the resulting tissue.

The key advantage of the 3D printed spheroid, cage-like structures, which are around a third of a millimetre in diameter, is that they’ve enabled the researchers in Austria to form combinable, compact building blocks from which to grow cartilage tissue.

Importantly, the team at TU Wien also showed that when combined, neighbouring spheroids actually grow together, with the cells from one spheroid migrating to another, connecting in a closed, continuous structure. [2]

The 3D printed plastic scaffolds provide mechanical stability to the tissue as it continues to grow, up until the point at which they are no longer needed. The spheroids then degrade, leaving behind cartilage tissue shaped in the way desired.

A huge breakthrough for facilitating the regenerative potential promised by stem cells  – particularly mesenchymal stem cells, which have the ability to differentiate into a range of specialised cells [3] – this new technique could be used in growing other tissues beyond cartilage into shapes required for repair at the cellular level.

For the time being, however, the researchers’ next aim is to attempt to use their 3D printed spheroids in the formation of tailormade pieces of cartilage tissue that can then be inserted into damaged areas of the body following injury.

If you’re interested in learning more about how saving stem cells for your baby could give them access to future regenerative treatments, download our free welcome pack below.

References

[1] Vienna University of Technology. “Artificial cartilage with the help of 3D printing.” ScienceDaily. ScienceDaily, 12 February 2024. <www.sciencedaily.com/releases/2024/02/240212133139.htm>

[2] Oliver Kopinski-Grünwald, Olivier Guillaume, Tamara Ferner, Barbara Schädl, Aleksandr Ovsianikov. Scaffolded spheroids as building blocks for bottom-up cartilage tissue engineering show enhanced bioassembly dynamics. Acta Biomaterialia, 2024; 174: 163 DOI: 10.1016/j.actbio.2023.12.001

[3] Vasanthan, Jayavardini et al. “Role of Human Mesenchymal Stem Cells in Regenerative Therapy.” Cells vol. 10,1 54. 31 Dec. 2020, doi:10.3390/cells10010054


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A new study conducted by researchers at the Mayo Clinic has found that stem cell treatment for patients with advanced heart failure offers an improved quality of life.

As many as 100,000 people are admitted to hospital in the UK every year due to heart attacks [1]. Heart attacks can lead to heart failure, where damage to cardiac muscles makes it harder for blood to be pumped around the body.


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Medical regulators in the UK have approved a gene-editing treatment involving bone marrow stem cells designed to cure two blood diseases, including sickle cell disease, in what is a world first.

The therapy, called Casgevy, has been given the green light by the Medicines and Healthcare products Regulatory Agency (MHRA) to treat sickle cell disease and beta thalassemia, two painful blood conditions. [1]


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20/01/2024 BlogNews

Stem cells and related research are all over the news, as amazing new applications for them are being studied, discovered and applied all the time.

This means you may have already heard of them. You may even know exactly what they are. But for anyone who wants a more in-depth knowledge of these potentially life-saving cells, read on.


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20/01/2024 BlogNews

According to the first large-scale study of its kind, pregnant women are at no greater risk of being admitted to hospital with severe coronavirus symptoms than other women.

The study examined more than 420 expectant mothers who were admitted to hospital with critical cases of COVID-19 between March 1 and April 14. Results show that only 10% of them required treatment in ICU. This figure is comparable to the statistics for other woman who are not pregnant.