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When you’re pregnant, you may be considering what you can do with your baby’s placenta and umbilical cord after birth. You might have heard of delayed cord clamping or even optimal cord clamping, as well as the possibility of storing the leftover blood from your baby’s umbilical cord, which is rich in stem cells. This is known as cord blood banking. Can these choices work together? Do you have to pick one or the other? Read this guest post by practicing Midwife, Angie Willis @theecomidwife to learn more.

What is Delayed Cord Clamping?

Previously, due to the increasing medicalisation of birth, it was common to cut and clamp the cord immediately. Over the last 20 years, however, more research has highlighted the benefits of leaving the cord attached to your baby after birth. When your baby is born, if you choose to delay the cord clamping, blood will continue to be pumped into your baby from the placenta through the cord until either it is cut or the placenta is delivered.

You will have three options when your baby is born;

Immediately clamp and cut the cord – no longer recommended. This may happen in the uncommon event of a baby needing resuscitation after birth. Ideally, this would be done attached to the cord. Still, most resuscitaires are separate from where the woman births and mattresses aren’t firm enough to maintain a good open airway in a baby in a hospital setting – and cords are only so long. In a home birth, if a woman is not in a pool of water or able to get out quickly, resuscitation can and should happen attached to the cord as long as there is enough room to provide the resuscitation, and there is a flat surface available.
Delayed cord clamping of around a minute or slightly longer – this is the recommended time from national guidelines like NICE, the resuscitation council, and both the RCM and RCOG for all babies to have, to aid the transition and to optimise iron levels, and have the benefits of delayed cord clamping.
Optimal cord clamping or ‘waiting for white‘ – The benefit of this is that all the placenta’s blood returns to your baby. Your baby receives all of the blood from the cord. Having all the benefits of optimum cord clamping can aid the delivery of your placenta, particularly if you have a physiological 3rd stage. Some cords can continue pulsating for as little as 4/5 minutes after birth – sometimes as long as 30-40 minutes for longer cords.

We recommend talking to your doctor and midwife for further information, but the length of time you wait is your choice if you and your baby remain well. The other alternative sometimes performed is umbilical cord milking, particularly if less than 1 minute of delayed clamping is undertaken. Cord milking is associated with higher haemoglobin (iron levels) at 6 weeks after birth than no cord milking when cord clamping
is one minute or less in length.

The benefits of delayed cord clamping

For most babies, the World Health Organisation recommends delayed cord clamping. This is also the position of the National Institute for Health and Clinical Excellence (NICE) in the UK, which aims to put “science and evidence at the heart of health and care decision making”, for example, in the National Health Services (NHS).

The benefits of delayed cord clamping are:

Higher haemoglobin concentration (more oxygen in the blood).
More iron in the blood essential for infant brain development for up to 12 months postpartum.
Higher birthweight.
Better blood pressure.
More stem cells which support growth and a developing immune system.
Improved fine motor skills at 6 months old.
Reduced pain during suturing of tears for the mother.
Reduced blood loss for the mother after delayed cord clamping.

In addition, delayed cord clamping for pre-term babies under 34 weeks improves survival by 33%! It also reduces:

The number of babies needing transfusions for anaemia.
Better circulation.
Reduced chance of intraventricular haemorrhage.
Reduced chance of necrotising enterocolitis.
Late-onset sepsis.

Risks associated with delayed cord clamping:

Previously, delayed cord clamping was thought to increase bleeding for women, but research has found this not to be true. Similarly, previous reviews found a much higher incidence of neonatal jaundice postnatally. More recent studies have found much smaller differences in jaundice rates at 3-5 days and in phototherapy rates (the most common treatment for jaundice) between those babies who had delayed or deferred cord clamping and those who did not. The most recent review also shows there was limited data to compare the other known risk factors for jaundice between the groups – highlighting that there may be biases in the delayed cord clamping groups, showing the small increased chance of jaundice than when compared to immediate cord clamping.

In most cases, if your baby has jaundice, it will get better within 10 to 14 days after birth, and it usually improves without treatment.

Jaundice happens because the additional red blood cells your baby needed inside you to have enough oxygen to grow and thrive during pregnancy and help them cope during labour is broken down after birth. A by-product of this is bilirubin, which is excreted via the baby’s urine and poo. If the levels become too high, the bilirubin can cross the blood brain barrier, which can have poor outcomes. Still, the chances of this in the UK are incredibly rare thanks to postnatal care and checks and having further tests like TBRs (a non-invasive light test to see how much bilirubin there is in the skin) or SBRs (a blood test to see how much bilirubin there is in the blood). Babies’ bilirubin levels are closely monitored after birth. If it is considered too high, they can be treated with lights to help the body break down excess bilirubin and remove it more easily. Regular feeding, good latch and attachment are all key to preventing and reducing the amount of jaundice. Feeding helps the excretion of the bilirubin in the urine and poo of the baby. Prematurity, birth before 39 weeks and feeding difficulties have a much higher prevalence of jaundice than delayed cord clamping is considered by midwives when undertaking postnatal care.

Are there times when delayed or optimal cord clamping cannot be done?

Yes, in emergency situations. This includes when there has been a placental abruption (where the placenta has come away from the uterus in labour), where there has been a vase previa which has been ruptured or where there is postpartum haemorrhage (the woman is bleeding too much). Similarly, if neonatal resuscitation is required without a
bedside resuscitaire in the unit or unable to have a safe space to perform resuscitation attached to the cord.

Is delayed cord clamping compatible with cord blood banking?

Cord blood banking is the process of taking the blood left in the umbilical cord once the baby is born and the cord is cut. It is a non-invasive process that will not impact your birth plan or your ability to bond with baby after birth. Cord blood collection only takes the blood that would otherwise become medical waste. Delayed cord clamping is compatible with cord blood collection and banking. Due to the delay, there may be less blood to collect if you defer cord clamping. However, you can still store what is left over. At this stage, we recommend CellsPlus, which is unique to Cells4Life and powered by patented TotiCyte technology. CellsPlus can recover up to 3x the amount of stem cells per cord blood collection when compared to other cord blood banking providers – so you can do more with less.

Conclusion

Delayed cord clamping and optimal cord clamping can impact the blood available for cord blood collection. After optimal cord clamping, the sample’s volume may be too small for processing or may not contain enough cells for therapeutic use, depending on the processing method used. Choosing Cells4Life’s CellsPlus, even smaller volumes of blood can be processed, delivering up to 2 to 3 times more stem cells at the point of treatment than other services available in the UK.

References

Herold, Abele, Graf (2023)
McDonald SJ, Middleton P, Dowswell T, Morris PS. Effect of timing of umbilical cord
clamping of term infants on maternal and neonatal outcomes. Cochrane Database of Systematic Reviews 2013, Issue 7. Art. No.: CD004074. DOI:
10.1002/14651858.CD004074.pub3. Accessed 25 August 2023

Shao, H., Gao, S., Lu, Q. et al. Effects of delayed cord clamping on neonatal jaundice,
phototherapy and early haematological status in term cesarean section. Ital J Pediatr 47, 115
(2021). https://doi.org/10.1186/s13052-021-01069-6

The power of cord blood stem cells has been heralded as a medical breakthrough in regenerative medicine. These unique cells can be pivotal in providing lifesaving treatments, particularly for siblings. In this blog post, we will delve into the topic of whether cord blood can be used for siblings.

Understanding the Power of Cord Blood Stem Cells

Cord blood, found in the umbilical cord and placenta post-childbirth, is a treasure trove of stem cells. They possess the extraordinary ability to self-renew and differentiate into other cell types, crucial in the body’s repair and renewal processes. Their potential use in treating over 80 diseases, including cancers , blood disorders, genetic disorders and immune deficiencies, makes them invaluable for future healthcare needs.

Can Cord Blood Be Used For Siblings?

Yes, indeed! Cord blood can be used for siblings and family members, offering hope in situations that may otherwise seem dire. The likelihood of finding a compatible match is significantly higher between siblings than unrelated donors. This compatibility can open doors to potential treatments for various health conditions and diseases, making cord blood preservation a worthwhile consideration for families.

Innovation and Advancements in Cord Blood Collection and Preservation

Over the years, there have been significant advancements in cord blood collection and stem cell banking techniques. These improvements have made it possible to store these precious cells effectively, maintaining their viability for future use even decades later. At Cells4Life, we utilize cutting-edge technology and adhere to stringent standards to ensure the highest cord blood collection and storage quality.

The Lifesaving Impact of Cord Blood on Siblings’ Lives

There are numerous real-life instances where cord blood transplantation between siblings has resulted in successful treatment outcomes. One such example involves a child suffering from Sickle Cell Anaemia, a hereditary blood disorder. She was successfully treated with her younger sibling’s cord blood stem cells, privately banked at birth. By utilizing a private cord blood bank to preserve your child’s cord blood, you’re potentially securing a lifesaving resource for their siblings.

A Lifelong Gift of Health for Your Children

Banking your baby’s cord blood is more than just an investment; it’s a lifelong gift of health for your children. Call us or download our Parents Guide for more information about the cord blood benefits and our cord blood banking services.

Secure a healthier tomorrow for your children with Cells4Life’s cord blood banking.

Introduction: An Exciting New Chapter

In this blog post, we delve into the second trimester – a period often considered the most enjoyable phase of pregnancy. This is a time of remarkable transformation, not just for you but especially for your growing baby and its ever-developing stem cells.

Embracing Comfort: A Respite from Early Pregnancy Symptoms

The second trimester brings relief from morning sickness and the persistent fatigue common in the first trimester. As these symptoms fade, expectant mothers often experience renewed energy. This is an excellent time to bond with your partner, family, and friends, as this reinvigorated phase often precedes a return of tiredness in the third trimester.

A Sneak Peek into Your Baby’s World: The Anomaly Scan

During this trimester, you’ll be invited for an anomaly scan, a detailed ultrasound to ensure your baby is developing correctly. This scan also often reveals the sex of your baby, should you choose to know. Plus, it offers an opportunity to get keepsake images of your baby[1].

The Stirrings of Life: Feeling Your Baby’s First Movements

One of the most anticipated milestones in the second trimester is feeling your baby move for the first time. Although some women may not experience this until the third trimester, the movements will become more noticeable as your baby grows.

Embracing Your Changing Body: The Visible Signs of Pregnancy

As your baby grows, so do you. During the second trimester, your pregnancy will become visibly noticeable. This transition often leads to a wardrobe update, as comfortable maternity clothes become a necessity.

Preparing for Arrival: Planning for Your Baby’s Birth

The second trimester is the perfect time to start preparing for your baby’s arrival. From considering the birth environment to arranging essential resources for your baby, this is a crucial period for planning. Whether you’re pondering a home birth, natural birth or caesarean section, water birth, or hospital birth, now is the time to explore your options.

Unlocking the Power of Stem Cells: Umbilical Cord Blood Storage

Booking your baby’s umbilical cord blood storage is an essential task to consider during the second trimester. At Cells4Life, we can collect your baby’s cord blood from over 200 NHS and private hospitals, offering flexible options for every type of birth.

Emphasizing the Importance: Stem Cell Cord Blood Banking

Stem cell cord blood banking is a powerful decision for your child’s future. The second trimester offers ample time to investigate and understand the immense potential of stem cell blood banks. Your baby’s umbilical cord blood is a valuable source of stem cells, which can play a pivotal role in treating various health conditions.

Conclusion: The Second Trimester – A Period of Preparation and Anticipation

The second trimester of pregnancy brings an exciting new chapter of growth and preparation. Now is a great time to book your baby’s umbilical cord blood storage and begin to think about where and how you would like to have your baby delivered. We are able to collect your baby’s cord blood from over 200 NHS and private hospitals. Whether you would like a home birth, caesarean section, water birth or hospital birth, you can store your baby’s cord blood with Cells4Life.

Sources:

https://www.nhs.uk/pregnancy/your-pregnancy-care/20-week-scan/

Private cord blood banking costs as little as £550 upfront, plus a small annual fee, and payment can be spread over 12 months, meaning it may be less expensive than you think.

We offer a huge range of cord blood banking packages, that include everything from cord blood only, all the way through to our Ultimate service; a comprehensive stem cell banking service costing £6,875 and including every perinatal stem cell tissue available – umbilical cord blood, cord tissue, placental tissue and amnion.

Want to know more about cord blood banking and the best plan to suit you? Read on!

What is cord blood banking?

Cord blood banking is the process of collecting, testing and storing blood and perinatal tissues from the umbilical cord and placenta after baby is born. This is to preserve precious stem cells that are found in the umbilical cord and placenta, and which are your baby’s own perfect biological match. It is a non-invasive procedure that is 100% safe for mum and baby.

This is high-level view of cord blood banking, for further information visit our Overview page.

Why should I bank my baby’s stem cells?

Collecting the cord blood stem cells is a once-in-a-lifetime opportunity. If not collected or donated, they end up becoming medical waste (literally thrown in the bin!).

Stem cells can currently treat over 80 conditions worldwide including blood disorders, blood cancers and immune disorders. Clinical trials are also revealing the further potential for these cells for treatment for things like brain injury and multiple sclerosis.

By storing privately, as opposed to donating publicly, your family will maintain access to your samples as needed, and your child will have a 100% genetic match should they ever get ill or injured. Better yet, their siblings will also have protection due their odds of being a full match and a high chance of being a partial match with their brother or sister.

How to pick your payment plan with Cells4Life?

Never be afraid to ask questions! After all, you are putting down a lot of money on this and it is a very important decision.

Here is a breakdown of all the Cells4Life packages:

Silver: Cord blood only

Just the cord blood is collected and stored.

Gold: Cord blood and cord tissue

Cord blood and portions of the umbilical cord itself are collected and stored.

Platinum: Cord blood, tissue, CellsPlus, multiple samples and dual locations

Cord blood and tissue are collected and stored, these samples are divided into multiple portions and stored across two facilities. You will also have access to the CellsPlus technology.

Ultimate: Cord blood, tissue, CellsPlus, placental cells and amnion, multiple samples and dual locations and BabyInsight

Cord blood and tissue are collected and stored, these samples are divided into multiple portions and stored across two facilities. You will also have access to the CellsPlus technology. On top of that, you get access to Cells4Life’s genetic screening called BabyInsight.

Our most popular package is our Platinum Service which includes CellsPlus.

Each of our main packages has an Access Plan equivalent. We wanted to ensure that everyone can store and these plans are a much more affordable cord blood banking option.

With Cells4Life you can store the cord blood and also tissue in multiple samples and store across two locations. You can also store your amnion and placental cells – which is unique to Cells4Life. The blood, tissue and placenta contain different but equally powerful cells. Existing clinical trials are beginning to show that for each – blood, tissue, and placenta – there could be different applications, with some being more effective than others. By storing them all, you can give yourself access to the greatest possible range of stem cells and treatments possible.

Do you want to add genetic screening for your baby? Our BabyInsight service comes as standard in our Ultimate plan. Otherwise, you can pay just £360 to test your child for five conditions, giving you the heads up on any potential health issues that might otherwise go unmanaged… until it’s too late.

Processing technology? All cord blood banks need to process the collected blood to isolate and then store the stem cells. At Cells4Life, we have an exclusive CellsPlus technology. Powered by TotiCyte, it is a revolution in cord blood processing, giving our customers up to 3x more stem cells at the point of therapy. CellsPlus can be added as a standalone extra, otherwise it comes as standard with our Platinum and Ultimate packages.

Any other fees? If you need a phlebotomist – someone who is licenced to collect the samples – this will cost you extra. The NHS won’t do this for you. We use a company called Phlebotomy UK which costs £300.

Storage term? Annual storage fees vary according to package and provider. At Cells4Life the annual fees range from £70 to £240 and all contracts are 25 years old.

NOTE – Should your sample not be viable for storage for any reason, we will contact you and inform you before arranging any refund. Typically, you will pay a non-refundable deposit, but in the event we cannot store your sample, we won’t charge you the full cost of your service.

What else is involved?

Once your samples are with us and have passed all the testing it’s not simply popped in a freezer. If it were that easy, you could do it at home.

Of course, the testing involved requires specialised equipment that costs money, trained staff, and specialist storage tanks that hold your sample at -170 degrees Celsius using liquid nitrogen. The liquid nitrogen needs constantly topping up too.

To keep your precious stem cells safe, we have to ensure all of our equipment and storage system are kept running and are fully functional. We want to ensure your samples stay secure and ready for use whenever.

If you are interested in banking with us at Cells4Life, get a FREE parent guide today or call 01444 873 950 to find out more.

Krembil Research Institute in Toronto, Canada has reported that stem cells can significantly ease the pain of knee osteoarthritis, after concluding a small-scale clinical trial.

Researchers set out to determine if mesenchymal stem cells (MSCs) derived from bone marrow could regenerate knee cartilage, which could thereby cure the condition.

The results add to a growing amount of research that suggest stem cells could dramatically improve – and even reverse – the symptoms of osteoarthritis, which is particularly significant considering how prolific the condition is.

What did the study involve?

12 patients were treated with a single MSC injection. Cells were extracted from their bone marrow, and then re-injected into the blood stream.

Researchers monitored patients over the course of 12 months and monitored their levels of inflammatory biomarkers and rate of cartilage breakdown. They also took regular MRI scans of the affected joints.

What were the results?

The therapy did not result in any cartilage regrowth, despite the fact that similar studies have encouraged regeneration. Researchers did, however, propose that this may have been because patients had end-stage osteoarthritis. More successful regeneration may have occurred if they suffered earlier stages of the condition.

The study did, however, measure significant reductions in pain levels in patients, as well as a dramatic decline in inflammation. There were also no serious adverse events, which demonstrates the safety of mesenchymal stem cells in treating knee osteoarthritis.

Stem cells & knee osteoarthritis

This is just the latest study which indicates stem cells can treat knee osteoarthritis.

Between 2005 and 2009, Centeno et al. also treated two groups of patients with orthopaedic conditions, such as osteoarthritis, by administering mesenchymal stem cell injections. There were just three cases of potential stem cell complications of 227 patients, all of which were either self-limited or easily remedied with simple therapeutic measures. The study concluded that stem cell transplantation did not cause any adverse reaction.

References

Mary Gooderham, (2019), ‘Using stem cells to fight osteoarthritis at the source’, Krembil Neuroscience Centre, accessed 11 November 2019, available at <https://www.uhn.ca/KNC/Research/Globe_Mail/Arthritis_Magazine/Pages/Using-stem-cells-fight-osteoarthritis.aspx>

Centeno et al., (2015), ‘A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions’, accessed 11 November 2019, available at <https://link.springer.com/content/pdf/10.1007%2Fs00264-016-3162-y.pdf>

Kate Middleton, Angelina Jolie and Giovanna Fletcher are just a handful of famous mothers who practiced hypnobirthing when they had their baby, and the NHS says that 40% of expectant mothers choose natural pain relief.

But what exactly is this growing practice and how does it work?

What is hypnobirthing?

The method is based on a book called Childbirth Without Fear, written by Dr Grantley Dick-Reid, an English obstetrician, in 1933. He argued that fear during labour results in blood and oxygen being diverted away from the uterus, which in turn leads to pain.

Instead, he suggested women should remain calm, helping their uterine muscles to relax and encouraging the body to produce oxytocin and endorphins.

Hypnobirthing is a popular method of pain management that mums-to-be can use during their labour and birth. Contrary to popular belief, it doesn’t involve hypnosis. Instead, it is a mix of visualisation, relaxation and deep breathing techniques.

What are some hypnobirthing techniques?

Controlled breathing

If you attend a hypnobirthing class, it is likely you will be taught how to breathe properly during your pregnancy.

Many teachers believe that breathing deeply through your nose and out through your mouth can relieve discomfort and help you stay calm.

Visualisation

Hypnobirthing often involves imagining the birth of your baby and the specifics of how you want it to happen. For some mums, visualisation can be specific whereas for others, it is more about the feeling they would like to have.

For instance, some pregnant parents might choose to picture holding their baby after the birth; others might walk through the entire process like a dress rehearsal.

Meditation

Studies suggest meditation can help you to concentrate, and mums-to-be use these techniques to focus on their body and baby during labour.

What are the benefits of hypnobirthing?

Proponents of the practice say that hypnobirthing can reduce your stress hormones. These hormones can curb your body’s production of oxytocin, which is a crucial chemical that helps progress labour.

It’s also possible that hypnobirthing will help you feel more prepared and by extension, more relaxed.

Some evidence also suggests hypnobirthing might reduce the chances of postnatal depression.

Is hypnobirthing effective?

Currently, there isn’t much research available about the effects of hypnobirthing. The NHS carried out a study in 2013 on 680 women, but the results were inconclusive.

For some mums-to-be, it’s key to a successful pregnancy. For others, it doesn’t make much difference.

Is hypnobirthing compatible with conventional pain relief?

Yes. Many mums use hypnobirthing alongside conventional pain relief to ensure they can fully relax.

How do I do hypnobirthing?

There are classes available across the UK – and many videos and articles freely available online. It is often advised you begin classes when you are 32 weeks pregnant.

Is hypnobirthing compatible with cord blood banking?

Hypnobirthing doesn’t affect your baby’s birth in any way; it is more about your state of mind. As such, a cord blood collection can take place as normal. Once your midwife cuts the umbilical cord, she can hand it to your phlebotomist.

The stem cell collection is simple, safe and non-invasive and because it takes place in a separate room, you can practice your hypnobirthing techniques such as meditation and visualisation without interruption or distraction.

References

NCT, ‘Hypnobirthing: where to start’, accessed 11 November 2019, available at <https://www.nct.org.uk/labour-birth/getting-ready-for-birth/hypnobirthing-where-start>

Baby Centre, ‘Can hypnobirthing make labour easier and less painful?’, accessed 11 November 2019, available at <https://www.babycentre.co.uk/x1046133/can-hypnobirthing-make-labour-easier-and-less-painful>

Jenna Mullan, ‘What is hypnobirthing?’, accessed 11 November 2019, available at <http://hypnobirthing.co.uk/what-is-hypnobirthing/>

This year, Cells4Life have decided to do something a little different to celebrate the third annual World Cord Blood Day on Wednesday 27^th November 2019… we are hosting a live Q&A on Facebook and Instagram to answer all of your cord blood banking questions. Here’s everything you need to know, including some information about World Cord Blood Day 2019.

What is World Cord Blood Day?

Medical history was made in 1988 when the world’s first cord blood transplant took place. You can read more about this incredible story here.

Since then, there have been over 35,000 cord blood transplants worldwide and in 2017, World Cord Blood Day was introduced to raise awareness about this potentially life-changing resource so that more families could discover cord blood banking for themselves.

This year’s World Cord Blood Day will provide a fresh opportunity for these families – as well as doctors, nurses and midwives – to discover the power of the umbilical cord as well as its current and future uses.

Throughout November, parents-to-be and healthcare professionals will be invited to take part in events all around the world that celebrate 31 years of cord blood transplants and the latest discoveries in regenerative medicine.

What happens on World Cord Blood Day?

Save the Cord Foundation and the organisers of World Cord Blood Day have incorporated a virtual online conference as part of the agenda for the day. This conference is free and open to the public and includes various guest speakers with specialists in the industry.

It will feature interviews from world-renowned cord blood experts, Dr. Joanne Kurtzberg and Dr. Karen Ballen, as well as insights into clinical trials for conditions such as autism, HIV, and spinal cord injury.

What are Cells4Life doing to celebrate World Cord Blood Day?

For the first time ever, Cells4Life are hosting our very own question and answer session that will stream live on Facebook and Instagram on Wednesday 27 November at 1.30pm.

During this event, we will be joined by our Chief Operations Officer, Claudia Rees, and our Chief Scientific Officer, Dr. Lesley-Ann Martin to answer your questions on everything related to cord blood.

You can ask us anything from how the collection process works to how cord blood is stored and how it could be used. We will be here to chat with you live to respond to all of these questions and more.

How can I get involved?

To be part of this exciting day, simply join our Facebook event for the latest updates and a notification when we go live.

This page will provide you with all-important updates and information about the live Q&A event as well as the link to the live stream. Be sure to submit your questions on the Facebook event page or by mentioning @Cells4LifeUK on social media prior to the event. You can also email us your questions.

Keep your eyes peeled on our Instagram story where we will give you another opportunity to ask us questions through the question-box feature. You will also be able to get in touch by commenting during the live stream.

References

World Cord Blood Day, Why do we need World Cord Blood Day?, accessed 25^th October 2019, <https://www.worldcordbloodday.org/learn-about-world-cord-blood-day.html>

World Cord Blood Day, Agenda for WCBD 2019 Virtual Online Conference, accessed 25^th October 2019, <https://www.worldcordbloodday.org/online-medical-conference-agenda.html>

PR News Wire, World Cord Blood Day 2019 to Celebrate Life-Saving Cord Blood Transplants and the Latest Research Results, accessed 25^th October 2019, <https://www.prnewswire.com/news-releases/world-cord-blood-day-2019-to-celebrate-life-saving-cord-blood-transplants-and-the-latest-research-results-300871339.html>

Save the Cord Foundation, Advancing Cord Blood Education, accessed 25^th October 2019, <https://www.savethecordfoundation.org>

Today is Chronic Obstructive Pulmonary Disease (COPD) day, which aims to raise awareness about COPD and improve COPD care across the globe. Chronic obstructive pulmonary disease is the name which describes a group of lung diseases including chronic obstructive airway disease, chronic bronchitis and emphysema.

COPD is mainly caused by smoking which irritates and damages the lungs. The more a person smokes, the greater their chances of developing COPD. While the condition can also be caused by genetic disorders, air pollution, fumes and dust, these cases are rarer [1].

Unfortunately, it is estimated that less than a third of people with COPD have been officially diagnosed. This is because many people who suffer from the condition simply dismiss their symptoms as a “smoker’s cough” [1].

COPD Facts

Around 3 million people in the UK have COPD. However, more than 2 million people are undiagnosed. [1]
COPD is one of the most common respiratory diseases in the UK. [1]
Most people are not diagnosed until they are in their 50’s. [1]
COPD is responsible for nearly 30,000 deaths each year in Great Britain. [2]
Approximately 15% of COPD is caused by workplace exposure. [2]
Work-related COPD accounts for 4,000 deaths in Great Britain each year. [2]
The UK is among the top 20 countries for COPD mortality worldwide. [6]

COPD and Stem Cells

Unfortunately there is no cure for COPD. However, research with stem cells could give hope to people affected by the disease.

The Lung Institute has used a patient’s own autologous stem cells to develop treatments for pulmonary conditions, including COPD. The stem cells, once returned to the patient, can target damaged lung tissue and have the potential to promote healing and improve lung function. [3]

A report by Jack Coleman, Jr., M.D., a doctor at the Lung Institute, found that 84 patients out of 100 had reported improved quality of life 3 months after receiving stem cell treatment. “Although research on the use of autologous stem cells is still in its early stages, it has shown substantive progress in treating patients with few, if any, adverse effects,” Dr. Coleman stated [4].

Stem cell research into COPD is taking place around the world. Today, there are 21 clinical trials investigating the application of stem cells in Chronic Obstructive Pulmonary Disease.

References

[1] http://www.nhs.uk/conditions/chronic-obstructive-pulmonary-disease/Pages/Introduction.aspx [2] http://www.hse.gov.uk/Statistics/causdis/copd/index.htm [3] https://lunginstitute.com/ [4] http://www.pressreleaserocket.net/lung-institute-white-paper-reveals-evidence-of-pulmonary-function-improvement-from-stem-cell-therapy/396932/ [5] https://clinicaltrials.gov/ct2/results?term=copd+stem+cell&Search=Search [6] https://www.blf.org.uk/support-for-you/copd/key-facts [7] https://statistics.blf.org.uk/copd

For some mums-to-be, a natural childbirth is the go-to option to feel in control of their pregnancy. If you’re choosing to push through the pain, you might be wondering what exactly that means for baby’s big arrival. Here is our guide to everything you need to know – including the logistics of natural childbirths and cord blood banking.

1. What is natural childbirth?

Simply put, a natural birth is when a mother chooses vaginal delivery without most – or in some cases, any – medical intervention. This can range from the choice of doctor to the type of pain relief the mother uses. Once upon a time, this practice was fairly common; nowadays, it is much less so.

2. How does a natural birth work?

There are two main methods for a successful natural birth.

Lamaze technique – this technique teaches that birth is normal, natural and healthy but stresses that it’s up to each mother to decide if she wants pain relief.
The Bradley method – this method focuses on a natural birth and the active participation of a ‘birth coach’. It aims to avoid all medications unless they are essential. The Bradley method also promotes a good diet and exercise during pregnancy, as well as relaxation and deep-breathing exercises to help mothers cope during labour.

3. Can natural birth be painless?

In most cases, it is highly unlikely that a natural birth would be entirely painless – mainly because mothers eschew all pain relief or assistance.

However, mums-to-be often take certain measures to mitigate their pain and improve the process. These could include hypnobirthing, yoga and meditation, massage, taking baths or showers, having a water birth, and visualising a pain-free pregnancy.

You might also want to consider using a doula, as it can reduce your need for pain medication, shorten labour and give you peace of mind thanks to their extra knowledge and skills.

4. What if I can’t handle the pain of a natural birth?

Of course, for some mums, the pain proves to be too much and if that is the case, doctors can still administer medication. Don’t feel bad if you can’t sustain the pain – labour lasts a long time, and there is no shame in needing some assistance.

5. Why choose natural childbirth? What are the benefits?

For some mums-to-be, foregoing medical interventions makes them feel in control of their baby’s birth. It can also be empowering for many expectant parents, as giving birth without pain relief is quite the achievement.

It can also be a way of bonding with your baby and birthing partner – you’ll almost definitely need their support to get through the pain.

For other expectant parents, natural birth is an attractive option because they are still able to move during pregnancy whereas epidurals confine them to their beds. This also means that the mother can move sooner after birth, whereas pain medication can leave them feeling groggy and numb.

The lack of pain medication also could make pushing easier and more effective, because the mother can still feel the sensations.

6. What are the risks?

Because natural childbirth involves eschewing medication and interventions, it is generally very safe. However, it can be dangerous if the mum-to-be ignores her birth team’s recommendations or refuses an intervention if something doesn’t go to plan.

Choosing natural birth can be a big decision, and it can therefore be disappointing if something goes wrong. It’s crucial, however, to keep an open mind because in an emergency, medical help could save you and your baby’s life.

It’s also worth remembering that choosing a natural birth means you’ll feel everything; the pain is often much more intense than anticipated and can often seem unbearable. Because of this, it might turn out that you require a general anaesthetic – this occurs if your baby’s heart rate drops and you haven’t had an epidural, as you made need a C-section.

7. Where can I have a natural childbirth?

There are three main options when it comes to a natural childbirth: giving birth in a hospital, a birth centre, or at home.

8. Is a natural birth compatible with cord blood banking?

Cord blood collection takes place after the birth, in a separate room. Once you have delivered the placenta, the cord is handed to your phlebotomist for the collection to take place. Because of this, stem cell collection doesn’t interfere with your birth plan – there is no medical intervention, and therefore no need to add anything unnatural to the process.

Pub Landlord comedian, Al Murray, appeared on Good Morning Britain recently to plea for more people to join the UK’s stem cell register after his 6-year-old nephew was diagnosed with leukaemia.

Little Finley Relf suffers from juvenile myelomonocytic leukaemia (JMML), a rare slowly-developing type of blood disorder that only occurs in young children.

Currently, the only effective treatment for the majority of JMML patients is an allogeneic haematopoietic stem cell transplant. Murray told the BBC that Finley is undergoing “gruelling” chemotherapy but the best chance of him fighting the disease would be through a stem cell transplant.

The critically ill youngster has been told by doctors that he needs to find a donor for a blood stem cell transplant before Christmas. However, only 2% of the UK’s entire population are currently on the blood stem cell registry.

Al Murray has been working hard to encourage more people to sign up and to raise awareness about the importance of stem cell transplants for children like Finley.

What is juvenile myelomonocytic leukaemia?

This rare blood disorder is characterised by the uncontrolled growth of white blood cells, which are abnormal and not fully mature. These abnormal white blood cells accumulate in the bone marrow, enter the blood stream and circulate around the body.

As such, the production and function of healthy blood cells is severely affected and the immune system and body’s ability to fight infection is weakened.

Whilst there is ongoing research investigating the factors that may result in this cancer, the exact cause of JMML is still unknown.

How can stem cells help to treat the disorder?

Children suffering from JMML can receive stem cells from a donor, who may be a closely matched family member or an unrelated donor.

Allogeneic stem cell transplants begin with an intense course of chemotherapy to kill off the JMML cells, which essentially resets the individual’s body. The donor’s stem cells are then transplanted through a drip into the bloodstream, travelling to the affected bone marrow where they begin to produce healthy blood cells.

These new stem cells effectively rebuild a healthy blood supply and immune system. Following treatment, approximately 50% of children with JMML achieve long-term remission.

To find out more about the powerful potential of stem cells, click here.

References

Cancer Research UK, (2019) ‘Juvenile Myelomonocytic Leukaemia’, accessed on 18^th November 2019, available at <https://www.cancerresearchuk.org/about-cancer/other-conditions/juvenile-myelomonocytic-leukaemia-jmml>
The Argus, (2019) ‘Emotional Al Murray appeals for blood stem cell donors as nephew battles cancer’, accessed on 18^th November 2019, available at <https://www.theargus.co.uk/news/18040867.emotional-al-murray-appeals-blood-stem-cell-donors-nephew-battles-cancer/>
Rare Disease Database, (2019) ‘Juvenile Myelomonocytic Leukaemia’ accessed on 18^th November 2019, available at <https://rarediseases.org/rare-diseases/juvenile-myelomonocytic-leukemia/>

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Stem Cell Blog

What is Delayed Cord Clamping?

You will have three options when your baby is born;

The benefits of delayed cord clamping

The benefits of delayed cord clamping are:

In addition, delayed cord clamping for pre-term babies under 34 weeks improves survival by 33%! It also reduces:

Risks associated with delayed cord clamping:

In most cases, if your baby has jaundice, it will get better within 10 to 14 days after birth, and it usually improves without treatment.

Are there times when delayed or optimal cord clamping cannot be done?

Is delayed cord clamping compatible with cord blood banking?

Conclusion

References

The power of cord blood stem cells has been heralded as a medical breakthrough in regenerative medicine. These unique cells can be pivotal in providing lifesaving treatments, particularly for siblings. In this blog post, we will delve into the topic of whether cord blood can be used for siblings.

Understanding the Power of Cord Blood Stem Cells

Can Cord Blood Be Used For Siblings?

Innovation and Advancements in Cord Blood Collection and Preservation

The Lifesaving Impact of Cord Blood on Siblings’ Lives

A Lifelong Gift of Health for Your Children

Banking your baby’s cord blood is more than just an investment; it’s a lifelong gift of health for your children. Call us or download our Parents Guide for more information about the cord blood benefits and our cord blood banking services.

Secure a healthier tomorrow for your children with Cells4Life’s cord blood banking.

Introduction: An Exciting New Chapter

In this blog post, we delve into the second trimester – a period often considered the most enjoyable phase of pregnancy. This is a time of remarkable transformation, not just for you but especially for your growing baby and its ever-developing stem cells.

Embracing Comfort: A Respite from Early Pregnancy Symptoms

A Sneak Peek into Your Baby’s World: The Anomaly Scan

During this trimester, you’ll be invited for an anomaly scan, a detailed ultrasound to ensure your baby is developing correctly. This scan also often reveals the sex of your baby, should you choose to know. Plus, it offers an opportunity to get keepsake images of your baby[1].

The Stirrings of Life: Feeling Your Baby’s First Movements

One of the most anticipated milestones in the second trimester is feeling your baby move for the first time. Although some women may not experience this until the third trimester, the movements will become more noticeable as your baby grows.

Embracing Your Changing Body: The Visible Signs of Pregnancy

As your baby grows, so do you. During the second trimester, your pregnancy will become visibly noticeable. This transition often leads to a wardrobe update, as comfortable maternity clothes become a necessity.

Preparing for Arrival: Planning for Your Baby’s Birth

Unlocking the Power of Stem Cells: Umbilical Cord Blood Storage

Booking your baby’s umbilical cord blood storage is an essential task to consider during the second trimester. At Cells4Life, we can collect your baby’s cord blood from over 200 NHS and private hospitals, offering flexible options for every type of birth.

Emphasizing the Importance: Stem Cell Cord Blood Banking

Conclusion: The Second Trimester – A Period of Preparation and Anticipation

Private cord blood banking costs as little as £550 upfront, plus a small annual fee, and payment can be spread over 12 months, meaning it may be less expensive than you think.

Want to know more about cord blood banking and the best plan to suit you? Read on!

What is cord blood banking?

This is high-level view of cord blood banking, for further information visit our Overview page.

Why should I bank my baby’s stem cells?

Collecting the cord blood stem cells is a once-in-a-lifetime opportunity. If not collected or donated, they end up becoming medical waste (literally thrown in the bin!).

Stem cells can currently treat over 80 conditions worldwide including blood disorders, blood cancers and immune disorders. Clinical trials are also revealing the further potential for these cells for treatment for things like brain injury and multiple sclerosis.

How to pick your payment plan with Cells4Life?

Never be afraid to ask questions! After all, you are putting down a lot of money on this and it is a very important decision.

Here is a breakdown of all the Cells4Life packages:

Silver: Cord blood only

Just the cord blood is collected and stored.

Gold: Cord blood and cord tissue

Cord blood and portions of the umbilical cord itself are collected and stored.

Platinum: Cord blood, tissue, CellsPlus, multiple samples and dual locations

Cord blood and tissue are collected and stored, these samples are divided into multiple portions and stored across two facilities. You will also have access to the CellsPlus technology.

Ultimate: Cord blood, tissue, CellsPlus, placental cells and amnion, multiple samples and dual locations and BabyInsight

Cord blood and tissue are collected and stored, these samples are divided into multiple portions and stored across two facilities. You will also have access to the CellsPlus technology. On top of that, you get access to Cells4Life’s genetic screening called BabyInsight.

Our most popular package is our Platinum Service which includes CellsPlus.

Each of our main packages has an Access Plan equivalent. We wanted to ensure that everyone can store and these plans are a much more affordable cord blood banking option.

Any other fees? If you need a phlebotomist – someone who is licenced to collect the samples – this will cost you extra. The NHS won’t do this for you. We use a company called Phlebotomy UK which costs £300.

Storage term? Annual storage fees vary according to package and provider. At Cells4Life the annual fees range from £70 to £240 and all contracts are 25 years old.

NOTE – Should your sample not be viable for storage for any reason, we will contact you and inform you before arranging any refund. Typically, you will pay a non-refundable deposit, but in the event we cannot store your sample, we won’t charge you the full cost of your service.

What else is involved?

Once your samples are with us and have passed all the testing it’s not simply popped in a freezer. If it were that easy, you could do it at home.

Of course, the testing involved requires specialised equipment that costs money, trained staff, and specialist storage tanks that hold your sample at -170 degrees Celsius using liquid nitrogen. The liquid nitrogen needs constantly topping up too.

To keep your precious stem cells safe, we have to ensure all of our equipment and storage system are kept running and are fully functional. We want to ensure your samples stay secure and ready for use whenever.

If you are interested in banking with us at Cells4Life, get a FREE parent guide today or call 01444 873 950 to find out more.

Krembil Research Institute in Toronto, Canada has reported that stem cells can significantly ease the pain of knee osteoarthritis, after concluding a small-scale clinical trial.

Researchers set out to determine if mesenchymal stem cells (MSCs) derived from bone marrow could regenerate knee cartilage, which could thereby cure the condition.

The results add to a growing amount of research that suggest stem cells could dramatically improve – and even reverse – the symptoms of osteoarthritis, which is particularly significant considering how prolific the condition is.

What did the study involve?

12 patients were treated with a single MSC injection. Cells were extracted from their bone marrow, and then re-injected into the blood stream.

Researchers monitored patients over the course of 12 months and monitored their levels of inflammatory biomarkers and rate of cartilage breakdown. They also took regular MRI scans of the affected joints.

What were the results?

The study did, however, measure significant reductions in pain levels in patients, as well as a dramatic decline in inflammation. There were also no serious adverse events, which demonstrates the safety of mesenchymal stem cells in treating knee osteoarthritis.

Stem cells & knee osteoarthritis

This is just the latest study which indicates stem cells can treat knee osteoarthritis.

References

Kate Middleton, Angelina Jolie and Giovanna Fletcher are just a handful of famous mothers who practiced hypnobirthing when they had their baby, and the NHS says that 40% of expectant mothers choose natural pain relief.

But what exactly is this growing practice and how does it work?

What is hypnobirthing?

The method is based on a book called Childbirth Without Fear, written by Dr Grantley Dick-Reid, an English obstetrician, in 1933. He argued that fear during labour results in blood and oxygen being diverted away from the uterus, which in turn leads to pain.

Instead, he suggested women should remain calm, helping their uterine muscles to relax and encouraging the body to produce oxytocin and endorphins.

Hypnobirthing is a popular method of pain management that mums-to-be can use during their labour and birth. Contrary to popular belief, it doesn’t involve hypnosis. Instead, it is a mix of visualisation, relaxation and deep breathing techniques.

What are some hypnobirthing techniques?