Emerging research suggests that stem cell-based therapies could offer a new approach to treating influenza-related lung damage.

Mesenchymal stem cells (MSCs) in particular have been shown to repair lung tissue and modulate the immune response, providing hope for quicker and more complete recoveries from severe flu infections.

What is Influenza?

Influenza, otherwise commonly referred to as flu, is a viral infection that affects the respiratory system.

Symptoms can range from mild to severe, and in some cases, can lead to complications like pneumonia.

Among the most common symptoms are a high temperature, headache, loss of appetite, diarrhoea, and sickness. [1]

Current approaches to influenza, like vaccines and antiviral medications, remain preventative, focusing primarily on prevention and symptom management rather than virus-related damage.

With excess deaths from flu reaching approximately 14,500 in the UK alone last year – higher on average than the five years before the pandemic – severe influenza episodes continue to be a cause for concern. [2]

Who is Most Affected by Influenza?

Influenza can affect anyone, but certain demographics are at higher risk of severe illness and complications:

– Elderly individuals: People aged 65 and older are more susceptible to severe influenza due to a naturally weakened immune system and the higher chance of suffering from chronic health conditions.

– Young children: Infants and young children under the age of 5, especially those under 2 years old, are at a higher risk because their immune systems are still developing.

– Pregnant women: Pregnancy can alter the immune system, making expectant mothers more vulnerable to severe influenza and its complications.

– Individuals with chronic health conditions: People with conditions such as asthma, diabetes, heart disease, and weakened immune systems (e.g., due to cancer treatment or HIV) are at increased risk. [3]

How Can Stem Cells Help?

Stem cells, in particular MSCs, have shown promise in treating a variety of conditions due to their unique properties.

MSCs are found in various tissues, including umbilical cord blood, cord tissue, bone marrow, and fat or adipose tissue.

These cells have the ability to transform into different cell types and aid in tissue repair and regeneration.

They can also modulate immune responses and reduce inflammation, making them ideal candidates for treating diseases like influenza that cause significant damage to lung tissue. [4]

Repairing Lung Damage

MSCs can promote the regeneration of lung tissue by differentiating into various cell types needed for repair, including lung epithelial cells – the cells which contribute to the microbial immune response in the lungs. [5]

They can also reduce the number of inflammatory cells in the lungs, aiding in faster recovery in addition to releasing cytokines and growth factors that stimulate the proliferation of lung cells, helping restore lung function. [6]

Immune Modulation

One of the critical benefits of MSCs is their ability to modulate the immune response.

During an influenza infection, the immune system’s response can sometimes be overwhelming, leading to excessive inflammation and further lung damage.

MSCs help balance this response by reducing harmful inflammation and inhibiting the proliferation of T cells, which are often involved in excessive immune responses. This modulation contributes to a more controlled and effective immune response, preventing extra damage. [7]

Current Research

Recent studies and clinical trials have shown promising results using mesenchymal stem cells (MSCs) to treat lung damage caused by influenza.

Promising Animal Studies

In animal studies, MSC therapy has shown significant potential in treating lung injuries. For instance, in mouse models of a condition called pulmonary arterial hypertension (PAH), which causes high blood pressure in the lungs, MSCs were able to reduce lung damage. They achieved this by modulating the immune response and decreasing inflammation. [8]

Research suggests that human placenta mesenchymal stem cells (hPMSCs) also have the ability to regulate immune responses by inhibiting the proliferation of T-cells, thereby reducing inflammation deriving from excessive immune response.

Another study looked at lung injury caused by a toxic gas called phosgene. The researchers found that MSCs helped the lung’s own stem cells to proliferate and repair the damaged tissue. [9]

Increasing Human Trials

Interest in using MSCs to treat virus-induced lung injury is growing, and the number of clinical trials is on the rise. One notable trial from 2020 found that MSCs significantly reduced mortality in patients suffering from acute respiratory distress syndrome (ARDS) caused by the H7N9 subtype of influenza A. [10]

Another trial for ARDS sought to investigate whether MSCs derived from the placenta and umbilical cord could be used to treat severely ill COVID-19 patients. They were found to be effective in rapidly reducing respiratory distress and inflammation. [11]

These trials indicate that MSCs are safe to use and hold great potential for treating lung damage from influenza, though proving their effectiveness is still a work in progress.

The Future of MSC Therapy for Influenza

Stem cells, particularly MSCs, offer a promising new frontier in treating influenza-related lung damage.

As research progresses, we may soon see MSC-based therapies becoming a standard part of influenza treatment, providing hope for quicker and more complete recoveries from severe flu infections.

Saving the stem cells from your baby’s umbilical cord blood, cord tissue, and placenta is the perfect way to ensure they have access to future treatments for conditions like influenza.

To find out more about how cord blood banking could safeguard your baby’s health, download our free Welcome Pack by filling out the form below.

References

[1] (2023, August 9). Flu. NHS. https://www.nhs.uk/conditions/flu/

[2] UK Health Security Agency (2023, June 22). Excess deaths associated with flu highest in 5 years. Gov.uk. https://www.gov.uk/government/news/excess-deaths-associated-with-flu-highest-in-5-years

[3] U.S. Centers for Disease Control and Prevention (2024, March 22). Key Facts About Influenza (Flu). CDC. https://www.cdc.gov/flu/about/keyfacts.htm

[4] Jiang, W., & Xu, J. (2020). Immune modulation by mesenchymal stem cells. Cell proliferation, 53(1), e12712. https://doi.org/10.1111/cpr.12712

[5] Mendez, J. J., Ghaedi, M., Steinbacher, D., & Niklason, L. E. (2014). Epithelial cell differentiation of human mesenchymal stromal cells in decellularized lung scaffolds. Tissue engineering. Part A, 20(11-12), 1735–1746. https://doi.org/10.1089/ten.TEA.2013.0647

[6] Neelabh Datta. (2024) Stem Cell Therapy for SARS-CoV-2 and Influenza Virus Infections. BIOI. Vol. 5(1). DOI: 10.15212/bioi-2024-0016

[7] Weiss Andreas Robert Rudolf , Dahlke Marc Hendrik. (2019) Immunomodulation by Mesenchymal Stem Cells (MSCs): Mechanisms of Action of Living, Apoptotic, and Dead MSCs. Frontiers in Immunology. Vol.10. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.01191

[8] Du Jun, et al. (2011) The Pathology of Bleomycin-Induced Fibrosis Is Associated with Loss of Resident Lung Mesenchymal Stem Cells That Regulate Effector T-cell Proliferation, Stem Cells, Volume 29, Issue 4, April 2011, Pages 725–735, https://doi.org/10.1002/stem.604

[9] Leeman, K.T., Pessina, P., Lee, JH. et al. (2019) Mesenchymal Stem Cells Increase Alveolar Differentiation in Lung Progenitor Organoid Cultures. Sci Rep 9, 6479. https://doi.org/10.1038/s41598-019-42819-1

[10] Chen, J., Hu, C., Chen, L., Tang, L., Zhu, Y., Xu, X., Chen, L., Gao, H., Lu, X., Yu, L., Dai, X., Xiang, C., & Li, L. (2020). Clinical Study of Mesenchymal Stem Cell Treatment for Acute Respiratory Distress Syndrome Induced by Epidemic Influenza A (H7N9) Infection: A Hint for COVID-19 Treatment. Engineering (Beijing, China), 6(10), 1153–1161. https://doi.org/10.1016/j.eng.2020.02.006

[11] Hashemian, S. R., Aliannejad, R., Zarrabi, M., Soleimani, M., Vosough, M., Hosseini, S. E., Hossieni, H., Keshel, S. H., Naderpour, Z., Hajizadeh-Saffar, E., Shajareh, E., Jamaati, H., Soufi-Zomorrod, M., Khavandgar, N., Alemi, H., Karimi, A., Pak, N., Rouzbahani, N. H., Nouri, M., Sorouri, M., … Baharvand, H. (2021). Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series. Stem cell research & therapy, 12(1), 91. https://doi.org/10.1186/s13287-021-02165-4

The results from a Phase I/II clinical trial suggests a new stem cell-based therapy has the power to treat osteoarthritis (OA).

The trial, which was conducted by Australian biotechnology company Magellan Stem Cells, demonstrated that their ‘off-the-shelf’ stem cell therapy MAG200 significantly improved joint function and reduced pain for sufferers, with sustained benefits observed over longer periods.

It’s hoped that the new therapy will revolutionise OA treatment, helping to improve quality of life outcomes for millions of OA sufferers around the world. [1]

What is osteoarthritis?

Osteoarthritis is a condition that causes joints to become stiff and painful.

Normally, the everyday wear and tear that joints undergo is repaired by the body itself. For those who suffer from osteoarthritis, however, the protective cartilage on the ends of bones breaks down over time, causing pain, stiffness, and swelling.

Osteoarthritis most commonly affects the small joints in the hands, hips, knees, and neck. [2]

An estimated 10 million people in the UK alone have osteoarthritis, with the majority suffering from knee OA. [3]

A leading cause of disability, knee OA is associated with significant economic and healthcare burdens, often leading to total knee replacement surgery. A study by NICE in 2020 found that 100,000 knee replacements were carried out every year, with 89% of these being total knee replacements. [4]

It’s hoped that the new MAG200 stem cell therapy will not only improve outcomes for knee OA sufferers, but also alleviate some of the resource strain caused by currently limited treatment options.

What is the new MAG200 stem cell therapy and how does it work? 

The MAG200 therapy involves the localised injection of mesenchymal stem cells (MSCs) derived from adipose tissue into the area of the knee.

MSCs have emerged in recent times as a promising approach to addressing the unmet clinical needs of OA, namely pain caused by inflammation and the absence of protective cartilage tissue.

Previous research has shown that MSCs not only have the ability to reduce proinflammatory cytokines, thereby suppressing the pain associated with knee OA, but also to secrete transforming growth factor (TGFβ1) which helps with local tissue repair. [5]

These abilities make mesenchymal stem cells ideal for application in the treatment of knee OA and, therefore, in the MAG200 therapy.

What were the findings of the trial?

40 patients participated in the double-blind randomised control trial, all of whom had a documented diagnosis of moderate knee OA.

A double blind trial is one in which neither the researchers, nor the participants, know who has been administered what until after the trial has finished. This is done to reduce the chance of biases.

The participants were split into four cohorts of 10, wherein 8 were given MAG200, and 2 were given a placebo.

Following the application of MAG200, participants who had experienced a clinically meaningful improvement in either the pain or functionality associated with their OA were invited to respond using a variety of rating scales at months 1,3,6,9, and 12. [6]

A subsequent statistical analysis of responses, in addition to analysis of MRI data to measure improvements in tissue repair, demonstrated substantial benefits of MAG200, including:

• Sustained pain improvement of 58% at 12 months of follow-up.

• Doubling of quality of life scores for patients who received the stem cell treatment.

• Potential to halt the progression of osteoarthritis, with improvements in cartilage volume observed in treated patients.

Long-term follow-up demonstrated that the improvements from a single injection of donor stem cells were maintained beyond four years, highlighting the therapy’s durability and efficacy. [7]

What are the next steps for the MAG200 therapy?

According to a press release, Magellan Stem Cells hopes that future research will show the reproducibility of their results and validate their findings, paving the way for the rollout of MAG200 in Australia, beyond clinical trials.

Considered an ‘off-the-shelf’ therapy, it’s hoped that MAG200 will also have a considerable impact in the treatment of knee and other forms of OA, alleviating significant socioeconomic burdens associated with current OA treatments in the process. [8]

What does this mean for cord blood banking?

Although the mesenchymal stem cells used for the MAG200 therapy were derived from adipose donor tissue, mesenchymal stem cells are also found in umbilical cord blood and cord tissue, and could theoretically be used in autologous OA treatments (treatments using a patient’s own stem cells).

In fact, a 2021 study published in Nature’s open-access Scientific Reports Journal showed that an implantation of umbilical cord blood derived mesenchymal stem cells was more effective in treating knee OA than a high tibial osteotomy, a surgical procedure to realign the knee. [9]

Another study from 2023 found that mesenchymal stem cells from umbilical cord blood could enhance cartilage regeneration and reduce inflammation for sufferers of OA and were stipulated as being better equipped to both proliferate and differentiate than other sources of stem cells. [10]

While the MAG200 therapy is an allogeneic therapy, using donor stem cells, there is research to suggest that autologous mesenchymal stem cell treatments for OA using a patient’s own stem cells display clinically significant improvements across numerous parameters. [11]

This is good news if you’re considering saving your baby’s stem cells as it means that access to future treatments for conditions like OA could depend on whether a patient has their own stem cells available for use or not.

Saving your baby’s own stem cells also eliminates the risk of rejection in treatment, as your baby will always be a perfect match for their own stem cells.

To find out more about how cord blood banking could safeguard the health of your baby, sign up using the form below for a free Welcome Pack.

References

[1] Julien Freitag, et al., Safety and efficacy of an allogeneic adipose-derived mesenchymal stem cell preparation in the treatment of knee osteoarthritis: A Phase I/IIa randomised controlled trial, Osteoarthritis and Cartilage Open, Volume 6, Issue 3, 2024, 100500, ISSN 2665-9131, https://doi.org/10.1016/j.ocarto.2024.100500. (https://www.sciencedirect.com/science/article/pii/S2665913124000670)

[2] (2023, March 20). Overview: Osteoarthritis. NHS. https://www.nhs.uk/conditions/osteoarthritis/

[3] (2024). The State of Musculoskeletal Health. Versus Arthritis. https://versusarthritis.org/about-arthritis/data-and-statistics/the-state-of-musculoskeletal-health/#:~:text=10%20million%20people%20in%20the%20UK%20have%20Osteoarthritis%20(OA)%2C,estimated%20to%20have%20Psoriatic%20Arthritis.

[4] (2020). Resource impact report: Joint replacement (primary): Hip, knee and shoulder (NG157). NICE (National Institute for Healthcare and Excellence). https://www.nice.org.uk/guidance/ng157/resources/resource-impact-report-pdf-8708810221#:~:text=2%20Currently%20over%20100%2C000%20knee,1%25%20were%20patellofemoral%20knee%20replacements.

[5] Freitag, J., Bates, D., Boyd, R. et al. Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy – a review. BMC Musculoskelet Disord 17, 230 (2016). https://doi.org/10.1186/s12891-016-1085-9

[6] Julien Freitag, et al., Safety and efficacy of an allogeneic adipose-derived mesenchymal stem cell preparation in the treatment of knee osteoarthritis: A Phase I/IIa randomised controlled trial, Osteoarthritis and Cartilage Open, Volume 6, Issue 3, 2024, 100500, ISSN 2665-9131, https://doi.org/10.1016/j.ocarto.2024.100500. (https://www.sciencedirect.com/science/article/pii/S2665913124000670)

[7] (2024, July 28). Australian researchers develop a donor stem cell therapy for the successful treatment of osteoarthritis – Magellan Stem Cells. Medianet. https://journalists.medianet.com.au/Release/1008949/8103088

[8] (2024, July 28). Australian researchers develop a donor stem cell therapy for the successful treatment of osteoarthritis – Magellan Stem Cells. Medianet. https://journalists.medianet.com.au/Release/1008949/8103088

[9] Jung, SH., Nam, BJ., Choi, CH. et al. Allogeneic umbilical cord blood-derived mesenchymal stem cell implantation versus microdrilling combined with high tibial osteotomy for cartilage regeneration. Sci Rep 14, 3333 (2024). https://doi.org/10.1038/s41598-024-53598-9

[10] Zhang, Pengwei et al. “Human umbilical cord mesenchymal stem cells promoting knee joint chondrogenesis for the treatment of knee osteoarthritis: a systematic review.” Journal of orthopaedic surgery and research vol. 18,1 639. 29 Aug. 2023, doi:10.1186/s13018-023-04131-7

[11] Prodromos, Chadwick et al. “Autologous Mesenchymal Stem Cell Treatment is Consistently Effective for the Treatment of Knee Osteoarthritis: The Results of a Systematic Review of Treatment and Comparison to a Placebo Group.” Medicines (Basel, Switzerland) vol. 7,8 42. 24 Jul. 2020, doi:10.3390/medicines7080042

New research has emerged showing that a stem cell-derived therapy may be able to treat the most common, and deadliest, form of liver cancer.

Scientists at the University of California, San Diego (UCSD) have developed a therapy using natural killer (NK) cells derived from stem cells to help combat hepatocellular carcinoma (HCC) – a highly treatment resistant tumour. [1]

While not yet studied in patients, it’s hoped that the therapy (which was tested both in vitro against HCC cell lines and in vivo in a mouse model) will be influential in future trials for treating HCC, and other solid tumours.

How does the stem cell therapy work?

Like other tumour cells, hepatocellular carcinoma cells inhibit the body’s immune cells from attacking them.

By creating this immunosuppressive environment, the tumour effectively prevents itself from being targeted by the body’s immune system, allowing it to propagate and spread.

This makes developing treatment for solid tumours difficult. Immunotherapies using chimeric antigen receptor (CAR)-expressing T-cells tend to be rather ineffective in combating solid tumours like HCC, rather than other forms of cancer, like blood cancers, for this reason. [2]

In order to make an effective therapy, the team of researchers realised that they had to prevent the HCC tumour from being able to create the immunosuppressive environment in the first place.

To do this, they engineered NK cells derived from human pluripotent stem cells and disabled their receptor for transforming growth factor beta (TGF-β), a protein that suppresses immune function and is abundant in HCC tumours.

Their findings showed that these modified NK cells had significantly better anti-tumor activity and improved survival rates in preclinical models than NK cells without the genetic modification. [3]

What impact will this liver cancer therapy have?

Being able to derive NK cells from induced pluripotent stem cells means that the new HCC therapy is an ‘off-the-shelf’ therapy, according to the researchers.

Unlike CAR T-cell therapy, which is a highly personalised immunotherapy, the genetically modified NK cell therapy could theoretically be mass produced, say the UCSD team.

This means the therapy could vastly improve not just the effectiveness of treatment outcomes, but could also potentially streamline the treatment process for patients.

Furthermore, the researchers’ findings suggest that the genetic disabling of the TGF-β receptor could be effective in treating other types of solid tumour which, like HCC, create immunosuppressive environments.

The team anticipate that future clinical trials will build upon their research, taking their findings and applying them in the development of both NK cell and CAR-T cell therapies for a range of solid tumours.

Regenerative medicine and cord blood banking

Research like this highlights the importance of stem cells in driving future medical breakthroughs.

Much like the induced pluripotent stem cells in this study, the stem cells in your baby’s umbilical cord blood are able to differentiate into a range of cell types, including NK cells. [4]

Saving these stem cells for your baby provides them with the best chance of accessing more of the cutting edge therapies of the future.

By saving their stem cells, you can be secure in the knowledge that they’ll always have cells from their own perfect donor match available: themselves.

To find out more about saving stem cells for your baby fill out the form below to request your FREE Welcome Pack.

References

[1] University of California – San Diego. “Stem cell-derived therapy shows promise against treatment-resistant liver cancer.” ScienceDaily. ScienceDaily, 9 July 2024. <www.sciencedaily.com/releases/2024/07/240709184232.htm>.

[2] Lionel A. Kankeu Fonkoua, Olivia Sirpilla, Reona Sakemura, Elizabeth L. Siegler, Saad S. Kenderian, CAR T cell therapy and the tumor microenvironment: Current challenges and opportunities, Molecular Therapy – Oncolytics, Volume 25, 2022, Pages 69-77, ISSN 2372-7705, https://doi.org/10.1016/j.omto.2022.03.009. (https://www.sciencedirect.com/science/article/pii/S2372770522000511)

[3] Jaya Lakshmi Thangaraj, Michael Coffey, Edith Lopez, Dan S. Kaufman, Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells, Cell Stem Cell, 2024, ISSN 1934-5909, https://doi.org/10.1016/j.stem.2024.06.009. (https://www.sciencedirect.com/science/article/pii/S1934590924002170)

[4] Zhao, Xiaoyan et al. “Cord-Blood Natural Killer Cell-Based Immunotherapy for Cancer.” Frontiers in immunology vol. 11 584099. 22 Oct. 2020, doi:10.3389/fimmu.2020.584099

The results from a new study into treating atopic dermatitis (AD) – the most common form of eczema – suggest that mesenchymal stem cells are effective in combatting AD symptoms.

The phase 1/2 trial, which aimed to treat patients suffering from moderate to severe AD symptoms, utilised human bone marrow-derived clonal mesenchymal stem cells (hcMSCs) which were delivered to patients via infusion.

Researchers believe that this treatment method is highly promising in improving symptoms of the chronic condition, which is estimated to affect approximately 2.6% of the population (204 million people) worldwide. [1]

What is atopic dermatitis?

Atopic dermatitis, also known as atopic eczema, is a condition that causes the skin to become dry, cracked, and itchy.

The most common form of eczema in children, atopic dermatitis is a long term condition which can also arise for the first time during adulthood.

The exact causes of AD remain unknown, though it’s thought that it may run in families.

Environmental factors such as the use of certain soaps and cleaning products, the weather, and stress have been shown to be triggers for AD flare ups, and those who suffer from AD often also suffer from hay-fever and asthma.

Current treatment options for AD are limited, with the majority focusing on the alleviation or management of symptoms. Self-care practices, such as avoiding triggers and trying not to scratch, along with the use of moisturisers (emollients) and topical medicines are most commonly recommended to help combat AD symptoms. [2]

In many cases, AD often improves over time, but the current lack of effective treatment options, in addition to the widespread prevalence of the condition and its impact on sufferers’ quality of life, means that finding new ways to combat AD is imperative.

What did the new study find?

The study was conducted in two phases.

Phase 1

• This phase saw 20 patients receive high and low doses of hcMSCs via infusions every two weeks.

• Both high-dose and low-dose application was effective, with 67-70% of both groups displaying a 50% improvement in symptoms.

Phase 2

Phase 2 expanded to 72 patients, half of whom were given the low-dose, and the other half a placebo, with some interesting results:

• 58% of patients who had the low-dose experienced over 50% improvement in symptoms compared to the placebo group, of which only 32% experienced a similar improvement.

• Further yet, 24% of patients who had the low-dose even saw improvements of over 90% in their symptoms thanks to the treatment, compared to only 6% from the placebo group.

Overall, the results of the trial suggest that low doses of hcMSCs can dramatically improve symptoms of AD in sufferers whose condition is moderate to severe. [3]

How does the treatment work? 

Mesenchymal stem cells have the ability to regulate the immune system. They interact with various immune cells and help reduce inflammation. Previous studies have shown these cells can lower inflammation in conditions like pancreatitis and improve symptoms in animal models of AD. [4] [5] [6] [7]

In this study, researchers hoped to build upon these previous findings by using mesenchymal stem cells derived from bone marrow in order to help with the immunomodulation necessary for improving AD symptoms.

What’s next for the new AD treatment?

While these results are promising, larger studies are needed to confirm the long-term benefits and safety of this treatment. However, this research opens up an exciting new avenue for eczema treatment that could significantly improve patients’ quality of life.

Cord blood banking and mesenchymal stem cells

The mesenchymal stem cells used in this study come from bone marrow, but they can also be found in a baby’s umbilical cord.

In 2017, a trial showed that mesenchymal stem cells from umbilical cord blood could effectively treat moderate to severe AD. [8]

These mesenchymal stem cells can become various types of specialised cells, from muscle tissue to nerve cells, making them ideal for regenerative therapies.

By saving these stem cells at birth, you can provide your child with access to future advanced treatments.

To learn more, fill out the form below to receive a free Welcome Pack. This pack will explain how stem cell collection works, the benefits of storing stem cells, and current treatments using stem cells. It only takes a moment, but it could be the best decision you make for your child’s future.

References

[1] A study about how many people around the world have atopic dermatitis, British Journal of Dermatology, Volume 190, Issue 1, January 2024, Page e6, https://doi.org/10.1093/bjd/ljad462

[2] (2023, November 11). Overview: Atopic eczema. NHS. https://www.nhs.uk/conditions/atopic-eczema/

[3] Hebebrand, M. (2024, July 8). Promising Phase 1/2 Trial Results of Stem Cells for AD. Dermatology Times. https://www.dermatologytimes.com/view/promising-phase-1-2-trial-results-of-stem-cells-for-ad

[4] Hyun-Min Seo, et al. Phase 1/2 trials of human bone marrow–derived clonal mesenchymal stem cells for treatment of adults with moderate to severe atopic dermatitis, Journal of Allergy and Clinical Immunology,2024,ISSN 0091-6749, https://doi.org/10.1016/j.jaci.2024.06.013. (https://www.sciencedirect.com/science/article/pii/S0091674924006377)

[5] Il Sang Shin, et al., Human Bone Marrow–derived Clonal Mesenchymal Stem Cells Decrease the Initial C-Reactive Protein Level in Patients With Moderately Severe to Severe Acute Pancreatitis, Gastroenterology, Volume 164, Issue 7, 2023, Pages 1317-1320.e2, ISSN 0016-5085, https://doi.org/10.1053/j.gastro.2023.02.009. (https://www.sciencedirect.com/science/article/pii/S0016508523001439)

[6] Na, K., Yoo, H., Zhang, Y. et al. Bone marrow-derived clonal mesenchymal stem cells inhibit ovalbumin-induced atopic dermatitis. Cell Death Dis 5, e1345 (2014). https://doi.org/10.1038/cddis.2014.299

[7] Song, Jy., Kang, H.J., Ju, H.M. et al. Umbilical cord-derived mesenchymal stem cell extracts ameliorate atopic dermatitis in mice by reducing the T cell responses. Sci Rep 9, 6623 (2019). https://doi.org/10.1038/s41598-019-42964-7

[8] Hyung-Sik Kim, Ji Hyun Lee, Kyoung-Hwan Roh, Hee Jin Jun, Kyung-Sun Kang, Tae-Yoon Kim, Clinical Trial of Human Umbilical Cord Blood-Derived Stem Cells for the Treatment of Moderate-to-Severe Atopic Dermatitis: Phase I/IIa Studies, Stem Cells, Volume 35, Issue 1, January 2017, Pages 248–255, https://doi.org/10.1002/stem.2401

It was announced this month that the results of research into a new stem cell based therapy for Hirschsprung disease – a rare condition affecting bowel movement – were promising.

Conducted by teams from University College London and the University of Sheffield, the research focuses on transplanting stem cell-derived precursor nerve cells into gut tissue. [1]

What is Hirschsprung disease?

Hirschsprung disease is an intestinal condition where an absence of nerves in parts of the intestine means the bowel can’t contract, leaving sufferers of Hirschsprung with difficulty passing stool. This can lead to constipation and, even more worryingly, enterocolitis – a bowel infection causing inflammation and, in some cases, sepsis which can be fatal. [2]

Hirschsprung disease is usually identified within the first few months of birth in newborns but may also be diagnosed later in childhood.

Current treatment options are limited, with surgery an inevitable eventuality in most cases.

Whilst the condition is rare – it’s estimated only 1 in every 5,000 newborns have Hirschsprung disease – the lack of available treatment options makes attempts to formulate an alternative therapy even more pressing for sufferers. [3]

What is the new stem cell therapy and how does it work?

The new therapy being trialed by researchers involves generating nerve cell precursors from human pluripotent stem cells (hPSCs).

Because stem cells have the unique ability to differentiate into other specialised cells in the body, they are ideal for regenerating or replacing cells that are lost or damaged through disease.

The researchers at the University of Sheffield isolated and used RNA sequencing to differentiate the stem cells into enteric nervous system (ENS) precursor cells.

These cells were then transferred to UCL, where they were transplanted into prepared gut tissue in the hope that they would integrate and develop into fully fledged nerves. [4]

What were the results of the stem cell transplant?

The team of researchers found that following transplantation of the stem cell-derived nerve precursor cells into gut tissue samples, the transplanted tissue was better able to contract in response to electric stimulation than the control tissue. [5]

This suggests that the transplantation of the stem cell-derived nerve cell precursors into the tissue improved its functionality to the point of counteracting the negative effects of Hirschsprung disease.

Following this success, the researchers will be looking for additional funding to move into the clinical trial stage, where it’s hoped they’ll be able to demonstrate the viability of the therapy in human subjects. [6]

This is just one of many ongoing studies in which the plasticity of stem cells is being harnessed to bring about the next generation of regenerative therapies for conditions ranging from diabetes to stroke, heart disease to cancer.

To find out about how you could safeguard your baby’s access to future medicine by saving their stem cells, fill out the form below to request your free Welcome Pack.

References

[1] Davis, S. (2024, July 1). Important step forward in stem cell therapy for rare bowel disease. University of Sheffield. https://www.sheffield.ac.uk/news/important-step-forward-stem-cell-therapy-rare-bowel-disease

[2] (2024, April 26). Hirschsprung’s Disease. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/9844-hirschsprung-disease

[3] Hirschsprung’s Disease. NHS Manchester University. https://mft.nhs.uk/rmch/services/manchester-centre-for-neonatal-surgery/conditions-we-treat-at-mcns/hirschsprungs-disease/

[4] (2024, June 28). Important step forward in stem cell therapy for rare bowel disease. Health Tech World. https://www.htworld.co.uk/news/research-news/important-step-forward-in-stem-cell-therapy-for-rare-bowel-disease/

[5] (2024, June 28). Stem cell therapy shows promise for hirschsprung disease. Open Access Government. https://www.openaccessgovernment.org/stem-cell-therapy-shows-promise-for-hirschsprung-disease/178690/

[6] Jevans B, Cooper F, Fatieieva Y, et alHuman enteric nervous system progenitor transplantation improves functional responses in Hirschsprung disease patient-derived tissueGut Published Online First: 30 May 2024. doi: 10.1136/gutjnl-2023-331532